TSP1-producing B cells show immune regulatory property and suppress allergy-related mucosal inflammation

• DOI: 10.1038/srep03345
• Publication Date: 2013-11-26T10:11:55Z
• Authors: Huan-Ping Zhang; Yingying Wu; Jiangqi Liu; Jing Jiang; Xiao-Rui Geng; Gui Yang; Lihua Mo; Zhi-Qiang Liu; Zhi-Gang Liu; Ping-Chang Yang
• Keywords: Inflammation; 0301 basic medicine; B-Lymphocytes; Cholera Toxin; Mice, Inbred BALB C; Interleukin-13; Ovalbumin; Dendritic Cells; Lymphocyte Activation; T-Lymphocytes, Regulatory; Article; 3. Good health; Intestines; Mice; 03 medical and health sciences; B7-1 Antigen; Immune Tolerance; Receptors, Complement 3b; Animals; B7-2 Antigen; Immunotherapy; Interleukin-4; Interleukin-5; Food Hypersensitivity

Specific immunotherapy (SIT) is the only specific remedy for the treatment of allergic diseases currently. B cells are important immune cells in the immunity. The role of B cells in immune regulatory activities has not been fully understood yet. This study aims to elucidate the role of the thrombospondin (TSP)1-producing B cells in the immune regulatory role of SIT. The results showed that after SIT, the frequency of CD35(+) B cells was increased in the intestine of mice with food allergy. The CD35(+) B cells expressed TSP1 after exposure to specific antigens. Co-culture with the TSP1-producing CD35(+) B cells decreased the levels of CD80/CD86 in dendritic cells; the cells convert naïve CD4(+) T cells to regulatory T cells to inhibit allergic inflammation in the intestine.