Targeting microRNA-23a to inhibit glioma cell invasion via HOXD10

• DOI: 10.1038/srep03423
• Publication Date: 2013-12-05T10:10:34Z
• Authors: Xing Hu; Dan Chen; Yanhui Cui; Zhiyuan Li; Jufang Huang
• Keywords: U87

Abstract Glioma is the most frequent primary brain tumor. Recently, upregulation of microRNA (miR)-23a was found to be associated with glioma, but molecular mechanism by which miR-23a promotes glioma growth remains unveiled. In present study, we that significantly upregulated in tissues compared their matched adjacent tissues. also highly expressed cell lines SHG44, U251 and U87 cells. Moreover, identified homeobox D10 (HOXD10) as a novel target for miR-23a. The expression HOXD10 reduced negatively regulates protein We further showed miRNA-23a promoted invasion, at least partially, directly targeting modulating MMP-14. These findings suggest may serve promising therapeutic glioma.