Ultrahigh relaxivity and safe probes of manganese oxide nanoparticles for in vivo imaging

• DOI: 10.1038/srep03424
• Publication Date: 2013-12-05T10:07:38Z
• Authors: J. Xiao; X. M. Tian; C. Yang; P. Liu; N. Q. Luo; Y. Liang; H. B. Li; D. H. Chen; C. X. Wang; L. Li; G. W. Yang
• Keywords: Male; Contrast Media; Metal Nanoparticles; Oxides; 02 engineering and technology; Magnetic Resonance Imaging; 01 natural sciences; Article; 0104 chemical sciences; Disease Models, Animal; Mice; Manganese Compounds; Neoplasms; Animals; Heterografts; Female; 0210 nano-technology

Mn-based nanoparticles (NPs) have emerged as new class of probes for magnetic resonance imaging due to the impressive contrast ability. However, reported NPs possess low relaxivity and there are no immunotoxicity data regarding agents. Here, we demonstrate ultrahigh water protons 8.26 mM(-1) s(-1) from Mn3O4 synthesized by a simple green technique, which is twice higher than that commercial gadolinium (Gd)-based agents (4.11 s(-1)) highest value date NPs. We first time these biocompatibilities both in vitro vivo satisfactory based on systematical studies intrinsic toxicity including cell viability human nasopharyngeal carcinoma cells, normal epithelium, apoptosis cells immunotoxicity. These findings pave way practical clinical diagnosis Mn safe imaging.