Understanding the antimicrobial mechanism of TiO2-based nanocomposite films in a pathogenic bacterium

• DOI: 10.1038/srep04134
• Publication Date: 2014-02-19T10:03:04Z
• Authors: Anna Kubacka; María Suárez Diez; David Rojo; Rafael Bargiela; Sergio Ciordia; Inés Zapico; Juan P. Albar; Coral Barbas; Vitor A. P. Marti...; Marcos Fernández-...; Manuel Ferrer
• Keywords: Proteome

Titania (TiO₂)-based nanocomposites subjected to light excitation are remarkably effective in eliciting microbial death. However, the mechanism by which these materials induce death and effects that they have on microbes poorly understood. Here, we assess low dose radical-mediated TiO₂ photocatalytic action of such evaluate genome/proteome-wide expression profiles Pseudomonas aeruginosa PAO1 cells after two minutes intervention. The results indicate impact gene-wide flux distribution metabolism is moderate analysed time span. Rather, triggers decreased a large array genes/proteins specific for regulatory, signalling growth functions parallel with subsequent selective ion homeostasis, coenzyme-independent respiration cell wall structure. present work provides first solid foundation biocidal titania may an design highly active photobiocidal nanomaterials.