Innovative strategy with potential to increase hemodialysis efficiency and safety

• DOI: 10.1038/srep04425
• Publication Date: 2014-03-21T10:05:53Z
• Authors: Hsiao-Chien Chen; Hsiu-Chen Lin; Hsi-Hsien Chen; Fu-Der Mai; Yu-Chuan Liu; Chun-Mao Lin; Chun-Chao Chang; Hui-Yen Tsai; Chih-Ping Yang
• Keywords: Aunt

Uremic toxins are mainly represented by blood urine nitrogen (BUN) and creatinine (Crea) whose removal is critically important in hemodialysis (HD) for kidney disease. Patients undergoing HD have a complex illness, resulting from: inadequate of organic waste, dialysis-induced oxidative stress membrane-induced inflammation. Here we report innovative breakthroughs efficient safe using plasmon-induced dialysate comprising Au nanoparticles (NPs)-treated (AuNT) water that distinguishable from conventional deionized (DI) water. The diffusion coefficient K3Fe(CN)6 saline solution can be significantly increased 2.76, to 4.62 × 10−6 cm s−1, AuNT prepared under illumination green light-emitting diodes (LED). In vitro experiments suggest the treatment times removals 70% BUN Crea reduced 47 59%, respectively, instead DI dialysate, while additionally suppressing NO release lipopolysaccharide (LPS)-induced inflammatory cells.