Suppression of metastasis by mirtazapine via restoration of the Lin-7C/β-catenin pathway in human cancer cells

• DOI: 10.1038/srep05433
• Publication Date: 2014-06-25T09:04:05Z
• Authors: Katsuhiro Uzawa; Atsushi Kasamatsu; Toshihiro Shimizu; Yasuhiro Saito; Takao Baba; Kentaro Sakuma; Kazuaki Fushimi; Yosuke Sakamoto; Katsunori Ogawara; Masashi Shiiba; Hideki Tanzawa
• Keywords: Mirtazapine

No definitive therapy exists to treat human metastatic tumors. We reported previously that down-regulation of Lin-7C is essential for metastasis squamous cell carcinomas (hSCCs). In this study, we investigated the chemical restoration expression and demonstrated its effectiveness suppressing potential in cancer cells. Ingenuity Pathway Analysis (IPA) identified candidate agents, i.e., apomorphine, caffeine, risperidone, quetiapine mirtazapine. Among them, mirtazapine, an antagonist HTR2C, upstream molecule Lin-7C, caused substantial up-regulation Lin-7C/β-catenin pathway a hSCC line melanoma-derived vitro did not contribute cellular proliferation. Moreover, antimetastatic effect mirtazapine these lines vivo also was evident multiple organs immunodeficient mice with no marked side effects. The current data offer novel information further study activity association enhanced activation