Accurate Inference of Local Phased Ancestry of Modern Admixed Populations

• DOI: 10.1038/srep05800
• Publication Date: 2014-07-23T09:04:09Z
• Authors: Yamin Ma; Jian Zhao; Jian-Syuan Wong; Li Ma; Wenzhi Li; Guoxing Fu; Wei Xu; Kui Zhang; Rick A. Kittles; Yun Li; Qing Song
• Keywords: Population stratification; Ancestry-informative marker; Genetic genealogy; Genome-wide Association Study; Genetic Association; Population Genetics

Population stratification is a growing concern in genetic-association studies. Averaged ancestry at the genome level (global ancestry) insufficient for detecting population substructures and correcting stratifications association Local phase are needed human genetic studies, but current technologies cannot be applied on entire data due to various technical caveats. Here we developed novel approach (aMAP, of Modern Admixed Populations) inferring local phased ancestry. It took about 3 seconds desktop computer finish analysis each with 1.4-million SNPs. This method also exhibits scalability larger datasets respect number SNPs, samples size reference panels. can detect lack proxy The accuracy was 99.4%. aMAP software has capacity analyzing 6-way admixed individuals. As biomedical community continues expand its efforts increase representation diverse populations as large whole-genome sequence grow rapidly, there an increasing demand rapid accurate genetics, pharmacogenomics, genetics clinical diagnosis.