Accurate Inference of Local Phased Ancestry of Modern Admixed Populations

Population stratification Ancestry-informative marker Genetic genealogy Genome-wide Association Study Genetic Association Population Genetics
DOI: 10.1038/srep05800 Publication Date: 2014-07-23T09:04:09Z
ABSTRACT
Population stratification is a growing concern in genetic-association studies. Averaged ancestry at the genome level (global ancestry) insufficient for detecting population substructures and correcting stratifications association Local phase are needed human genetic studies, but current technologies cannot be applied on entire data due to various technical caveats. Here we developed novel approach (aMAP, of Modern Admixed Populations) inferring local phased ancestry. It took about 3 seconds desktop computer finish analysis each with 1.4-million SNPs. This method also exhibits scalability larger datasets respect number SNPs, samples size reference panels. can detect lack proxy The accuracy was 99.4%. aMAP software has capacity analyzing 6-way admixed individuals. As biomedical community continues expand its efforts increase representation diverse populations as large whole-genome sequence grow rapidly, there an increasing demand rapid accurate genetics, pharmacogenomics, genetics clinical diagnosis.
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