Research of dose-effect relationship parameters of percutaneous microwave ablation for uterine leiomyomas - a quantitative study

• DOI: 10.1038/srep06469
• Publication Date: 2014-09-30T09:14:18Z
• Authors: Ma Xia; Zhang Jing; Han Zhi-yu; Yang Yu; Hao Yan-li; Xu Chang-tao; Xu Rui-fang; Zhang Bing-song; Dong Bao-wei
• Keywords: Adult; Leiomyoma; Uterus; Contrast Media; Dose-Response Relationship, Radiation; Middle Aged; Magnetic Resonance Imaging; Article; Radiography; 03 medical and health sciences; Treatment Outcome; 0302 clinical medicine; Humans; Female; Microwaves

Eighty eight patients with 91 uterine leiomyomas who underwent ultrasound-guided percutaneous microwave ablation (PMWA) treatment were prospectively included in the study in order to study the dose-effect relationship parameters (DERP) of PMWA for uterine leiomyomas and its relationship with T2-weighted MR imaging (T2WI). Based on the signal intensity of T2WI, uterine leiomyomas were classified as hypointense, isointense, and hyperintense. During ablation, leiomyomas were treated with quantitative microwave ablation (QMWA) energy of 50 w × 300 s or 60 w × 300 s. After QMWA, contrast-enhanced ultrasound (CEUS) was performed to evaluate DERP. No matter under 50 w × 300 s or 60 w × 300 s, quantitative microwave ablation volume (QMAV) of hyperintense leiomyoma was smaller than that of hypointense and isointense leiomyoma (P<0.016). For hypointense and isointense leiomyoma, QMAV of 60 w × 300 s was larger than that of 50 w × 300 s (P<0.05). DERPs obtained by T2WI can be used to guide the treatment of uterine leiomyoma by PMWA.