Radio frequency radiation-induced hyperthermia using Si nanoparticle-based sensitizers for mild cancer therapy

• DOI: 10.1038/srep07034
• Publication Date: 2014-11-13T12:13:02Z
• Authors: Konstantin P. Tam...; Liubov A. Osminkina; Sergey V. Zinovyev; Ksenia A. Maximova; Julia V. Kargina; Maxim B. Gongalsky; Yury Ryabchikov; Ahmed Al-Kattan; Andrey P. Sviridov; Marc Sentis; Andrey V. Ivanov; Vladimir N. Nikif...; Andrei V. Kabashin; Victor Yu Timoshenko
• Keywords: Nanomaterials

Offering mild, non-invasive and deep cancer therapy modality, radio frequency (RF) radiation-induced hyperthermia lacks for efficient biodegradable RF sensitizers to selectively target cells thus avoid side effects. Here, we assess crystalline silicon (Si) based nanomaterials as the RF-induced therapy. Using nanoparticles produced by mechanical grinding of porous ultraclean laser-ablative synthesis, report heating aqueous suspensions temperatures above 45-50°C under relatively low nanoparticle concentrations (<1 mg/mL) radiation intensities (1–5 W/cm2). For both types rate was linearly dependent on concentration, while laser-ablated demonstrated a remarkably higher than silicon-based ones whole range used from 0.01 0.4 mg/mL. The observed effect is explained Joule due generation electrical currents at nanoparticle/water interface. Profiting nanoparticle-based hyperthermia, demonstrate an treatment Lewis lung carcinoma in vivo. Combined with possibility involvement parallel imaging channels unique optical properties Si-based nanomaterials, proposed method promises new landmark development modalities mild