Quantitative Proteomic Analysis of Meningiomas for the Identification of Surrogate Protein Markers

• DOI: 10.1038/srep07140
• Publication Date: 2014-11-21T10:58:08Z
• Authors: Samridhi Sharma; Sandipan Ray; Aliasgar Moiyadi; Epari Sridhar; Sanjeeva Srivastava
• Keywords: Clusterin; Apolipoprotein E

Abstract Meningiomas are the most common non-glial tumors of brain and spine. Pathophysiology definite histological grading meningiomas frequently found to be deceptive due their unusual morphological features locations. Here for first time we report a comprehensive serum proteomic analysis different grades by using multiple quantitative immunoassay-based approaches obtain mechanistic insights about disease pathogenesis identify grade specific protein signatures. In silico functional revealed modulation vital physiological pathways including complement coagulation cascades, metabolism lipids lipoproteins, immune signaling, cell growth apoptosis integrin signaling in meningiomas. ROC curve demonstrated apolipoprotein E A-I hemopexin as efficient predictors Identified proteins like vimentin, alpha-2-macroglobulin, B antithrombin-III, which exhibited sequential increase malignancy meningiomas, could serve potential predictive markers.