Pre-pregnancy cytogenetic analysis of general couples in eastern China

• DOI: 10.1038/srep07224
• Publication Date: 2014-11-27T10:06:33Z
• Authors: Yan Yang; Hexi Wang; Min Gao; Shuangshan Xu; Xiaofen Xu; Xinyu Cao; Ying Tao
• Keywords: Klinefelter syndrome; Chromosomal analysis

The aim of this study was to investigate the contribution chromosomal anomalies and frequency particular types aberrations in general couples preparing for pregnancy make recommendations on basis medical literature. A total 6,198 were included present study. karyotypes generated from peripheral blood lymphocyte cultures cytogenetic analysis performed using G-banding. In 12,396 cases, detected 59 cases (0.48%, 59/12,396). Among them, translocation 0.35% (n = 43). Sex accounted 0.07% 9), including Klinefelter syndrome (KS) 4), Turner (TS) 4) XYY 1). others, inversions 6) deletion 1), 0.06%. Our indicates that clinically important defects are at a remarkable eastern China, suggesting pre-pregnancy should be routinely among area so informed decision can made, which will help improve quality pregnancy.