Re-emergent Human Adenovirus Genome Type 7d Caused an Acute Respiratory Disease Outbreak in Southern China After a Twenty-one Year Absence

• DOI: 10.1038/srep07365
• Publication Date: 2014-12-08T10:03:34Z
• Authors: Suhui Zhao; Chengsong Wan; Changwen Ke; Jason Seto; Shoaleh Dehghan; Lirong Zou; Jie Zhou; Zetao Cheng; Shuping Jing; Zhiwei Zeng; Jing Zhang; Xuan Wan; Xianbo Wu; Wei Zhao; Li Zhu; Donald Seto; Qiwei Zhang
• Keywords: Case fatality rate; Molecular Epidemiology

Human adenoviruses (HAdVs) are highly contagious pathogens causing acute respiratory disease (ARD), among other illnesses. Of the ARD genotypes, HAdV-7 presents with more severe morbidity and higher mortality than others. We report isolation identification of a genome type HAdV-7d (DG01_2011) from recent outbreak in Southern China. Genome sequencing, phylogenetic analysis restriction endonuclease (REA) comparisons past indicate has re-emerged China after an absence twenty-one years. Recombination reveals this differs 1950s-era prototype vaccine strains by lateral gene transfer, substituting coding region for L1 52/55 kDa DNA packaging protein HAdV-16. DG01_2011 descends both strain circulating Southwestern (2010) Shaanxi fatality (Northwestern China; 2009). Due to rates associated HAdV-7, surveillance, characterization these population-dense REA and/or whole sequencing strongly indicated. With accurate identifications specific HAdV types epidemiological database regional pathogens, along stability noted across time space, development, availability deployment appropriate vaccines needed.