Porphyrin conjugated SiC/SiOx nanowires for X-ray-excited photodynamic therapy

• DOI: 10.1038/srep07606
• Publication Date: 2015-01-05T10:09:18Z
• Authors: F. Rossi; E. Bedogni; F. Bigi; T. Rimoldi; L. Cristofolini; S. Pinelli; R. Alinovi; M. Negri; S. C. Dhanabalan; G. Attolini; F. Fabbri; M. Goldoni; A. Mutti; G. Benecchi; C. Ghetti; S. Iannotta; G. Salviati
• Keywords: Radiosensitizer

The development of innovative nanosystems opens new perspectives for multidisciplinary applications at the frontier between materials science and nanomedicine. Here we present a novel hybrid nanosystem based on cytocompatible inorganic SiC/SiOx core/shell nanowires conjugated via click-chemistry procedures with an organic photosensitizer, tetracarboxyphenyl porphyrin derivative. We show that this is efficient source singlet oxygen cell oxidative stress when irradiated 6 MV X-Rays low doses (0.4–2 Gy). in-vitro clonogenic survival assay lung adenocarcinoma cells shows 12 days after irradiation dose 2 Gy, population reduced by about 75% respect to control cells. These results demonstrate our approach very enhance radiation therapy effects cancer treatments.