Molecularly imprinted polymer decorated nanoporous gold for highly selective and sensitive electrochemical sensors

• DOI: 10.1038/srep07699
• Publication Date: 2015-01-09T10:03:21Z
• Authors: Yingchun Li; Yuan Liu; Jie Liu; Jiang Liu; Hui Tang; Cong Cao; Dongsheng Zhao; Yi Ding
• Keywords: Molecularly imprinted polymer; Nanoporous; Nanosensor; Electrochemical gas sensor

Electrochemical nanosensors based on nanoporous gold leaf (NPGL) and molecularly imprinted polymer (MIP) are developed for pharmaceutical analysis by using metronidazole (MNZ) as a model analyte. NPGL, serving the loading platform MIP immobilization, possesses large accessible surface area with superb electric conductivity, while electrochemically synthesized thin layer affords selectivity specific recognition of MNZ molecules. For determination, hybrid electrode shows two dynamic linear range 5 × 10−11 to 1 10−9 mol L−1 1.4 10−6 remarkably low detection limit 1.8 (S/N = 3). In addition, sensor exhibits high binding affinity towards excellent reproducibility stability. Finally, reliability MIP-NPGL is proved in real fish tissue samples, demonstrating potential proposed electrochemical sensors monitoring drug biological samples.