A statistically inferred microRNA network identifies breast cancer target miR-940 as an actin cytoskeleton regulator

• DOI: 10.1038/srep08336
• Publication Date: 2015-02-12T10:29:06Z
• Authors: Ricky Bhajun; Laurent Guyon; Amandine Pitaval; Eric Sulpice; Stéphanie Combe; Patricia Obeid; Vincent Haguet; Itebeddine Ghorbel; Christian Lajaunie; Xavier Gidrol
• Keywords: Small GTPase; Gene regulatory network

Abstract MiRNAs are key regulators of gene expression. By binding to many genes, they create a complex network co-regulation. Here, using network-based approach, we identified miRNA hub groups by their close connections and common targets. In one cluster containing three miRNAs, miR-612, miR-661 miR-940, the annotated functions co-regulated genes suggested role in small GTPase signalling. Although members this targeted same subset predicted showed that overexpression impacted cell fates differently. demonstrated enhanced phosphorylation myosin II an increase invasion, indicating possible oncogenic miRNA. On contrary, miR-612 miR-940 inhibit invasion. Finally, expression profiling human breast tissues was consistently downregulated cancer