Diversity in gut bacterial community of school-age children in Asia

0301 basic medicine Prevotella Health Professions FOS: Health sciences Gene Feces Cluster Analysis Bacteroides Child Phylogeny 2. Zero hunger Principal Component Analysis Ecology Life Sciences Biodiversity Diversity and Function of Gut Microbiome Infectious Diseases Impact of Food Insecurity on Health Outcomes Phylotype General Health Professions Carbohydrate Metabolism Medicine 16S ribosomal RNA DNA, Bacterial Asia Immunology 610 Real-Time Polymerase Chain Reaction Article Bile Acids and Salts 03 medical and health sciences Microbiome Diversity Biochemistry, Genetics and Molecular Biology Health Sciences Genetics Humans Molecular Biology Biology Gut flora Bacteria FOS: Clinical medicine Sequence Analysis, DNA Clostridium difficile Infection and Treatment Gastrointestinal Tract Lactobacillus FOS: Biological sciences Metagenome Bifidobacterium Metagenomics Zoology
DOI: 10.1038/srep08397 Publication Date: 2015-02-23T10:17:13Z
ABSTRACT
AbstractAsia differs substantially among and within its regions populated by diverse ethnic groups, which maintain their own respective cultures and dietary habits. To address the diversity in their gut microbiota, we characterized the bacterial community in fecal samples obtained from 303 school-age children living in urban or rural regions in five countries spanning temperate and tropical areas of Asia. The microbiota profiled for the 303 subjects were classified into two enterotype-like clusters, each driven by Prevotella (P-type) or Bifidobacterium/Bacteroides (BB-type), respectively. Majority in China, Japan and Taiwan harbored BB-type, whereas those from Indonesia and Khon Kaen in Thailand mainly harbored P-type. The P-type microbiota was characterized by a more conserved bacterial community sharing a greater number of type-specific phylotypes. Predictive metagenomics suggests higher and lower activity of carbohydrate digestion and bile acid biosynthesis, respectively, in P-type subjects, reflecting their high intake of diets rich in resistant starch. Random-forest analysis classified their fecal species community as mirroring location of resident country, suggesting eco-geographical factors shaping gut microbiota. In particular, children living in Japan harbored a less diversified microbiota with high abundance of Bifidobacterium and less number of potentially pathogenic bacteria, which may reflect their living environment and unique diet.
SUPPLEMENTAL MATERIAL
Coming soon ....
REFERENCES (64)
CITATIONS (216)
EXTERNAL LINKS
PlumX Metrics
RECOMMENDATIONS
FAIR ASSESSMENT
Coming soon ....
JUPYTER LAB
Coming soon ....