Diversity in gut bacterial community of school-age children in Asia
0301 basic medicine
Prevotella
Health Professions
FOS: Health sciences
Gene
Feces
Cluster Analysis
Bacteroides
Child
Phylogeny
2. Zero hunger
Principal Component Analysis
Ecology
Life Sciences
Biodiversity
Diversity and Function of Gut Microbiome
Infectious Diseases
Impact of Food Insecurity on Health Outcomes
Phylotype
General Health Professions
Carbohydrate Metabolism
Medicine
16S ribosomal RNA
DNA, Bacterial
Asia
Immunology
610
Real-Time Polymerase Chain Reaction
Article
Bile Acids and Salts
03 medical and health sciences
Microbiome Diversity
Biochemistry, Genetics and Molecular Biology
Health Sciences
Genetics
Humans
Molecular Biology
Biology
Gut flora
Bacteria
FOS: Clinical medicine
Sequence Analysis, DNA
Clostridium difficile Infection and Treatment
Gastrointestinal Tract
Lactobacillus
FOS: Biological sciences
Metagenome
Bifidobacterium
Metagenomics
Zoology
DOI:
10.1038/srep08397
Publication Date:
2015-02-23T10:17:13Z
AUTHORS (29)
ABSTRACT
AbstractAsia differs substantially among and within its regions populated by diverse ethnic groups, which maintain their own respective cultures and dietary habits. To address the diversity in their gut microbiota, we characterized the bacterial community in fecal samples obtained from 303 school-age children living in urban or rural regions in five countries spanning temperate and tropical areas of Asia. The microbiota profiled for the 303 subjects were classified into two enterotype-like clusters, each driven by Prevotella (P-type) or Bifidobacterium/Bacteroides (BB-type), respectively. Majority in China, Japan and Taiwan harbored BB-type, whereas those from Indonesia and Khon Kaen in Thailand mainly harbored P-type. The P-type microbiota was characterized by a more conserved bacterial community sharing a greater number of type-specific phylotypes. Predictive metagenomics suggests higher and lower activity of carbohydrate digestion and bile acid biosynthesis, respectively, in P-type subjects, reflecting their high intake of diets rich in resistant starch. Random-forest analysis classified their fecal species community as mirroring location of resident country, suggesting eco-geographical factors shaping gut microbiota. In particular, children living in Japan harbored a less diversified microbiota with high abundance of Bifidobacterium and less number of potentially pathogenic bacteria, which may reflect their living environment and unique diet.
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