Diversity in gut bacterial community of school-age children in Asia
Prevotella
Phylotype
DOI:
10.1038/srep08397
Publication Date:
2015-02-23T10:17:13Z
AUTHORS (29)
ABSTRACT
Abstract Asia differs substantially among and within its regions populated by diverse ethnic groups, which maintain their own respective cultures dietary habits. To address the diversity in gut microbiota, we characterized bacterial community fecal samples obtained from 303 school-age children living urban or rural five countries spanning temperate tropical areas of Asia. The microbiota profiled for subjects were classified into two enterotype-like clusters, each driven Prevotella (P-type) Bifidobacterium / Bacteroides (BB-type), respectively. Majority China, Japan Taiwan harbored BB-type, whereas those Indonesia Khon Kaen Thailand mainly P-type. P-type was a more conserved sharing greater number type-specific phylotypes. Predictive metagenomics suggests higher lower activity carbohydrate digestion bile acid biosynthesis, respectively, subjects, reflecting high intake diets rich resistant starch. Random-forest analysis species as mirroring location resident country, suggesting eco-geographical factors shaping microbiota. In particular, less diversified with abundance potentially pathogenic bacteria, may reflect environment unique diet.
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