Helicobacter pylori infection can affect energy modulating hormones and body weight in germ free mice

• DOI: 10.1038/srep08731
• Publication Date: 2015-03-04T10:45:33Z
• Authors: Yalda Khosravi; Shih Wee Seow; Arlaine Anne Amoyo; Kher Hsin Chiow; Tuan Lin Tan; Whye Yen Wong; Qian Hui Poh; Ignatius Mario Do...; Ralph M. Bunte; Sven Pettersson; Mun Fai Loke; Jamuna Vadivelu
• Keywords: Peptide YY

Abstract Helicobacter pylori , is an invariably commensal resident of the gut microbiome associated with gastric ulcer in adults. In addition, these patients also suffered from a low grade inflammation that activates immune system and thus increased shunting energy to host defense mechanisms. To assess whether H. infection could affect growth early life, we determined expression levels selected metabolic hormones germ free (GF) specific pathogen-free (SPF) mice without presence . Despite -infected (SPFH) display alteration metabolism (elevated leptin, insulin peptide YY) compared non-infected SPF mice, their curves remained same. SPFH displayed level eotaxin-1. Interestingly, GF infected (GFH) ghrelin PYY. However, contrast GFH showed reduced weight gain malnutrition. These preliminary findings show exposure alters life; but microbiota can attenuate retarding effect observed mice. Further investigations possible additional side effects are highly warranted.