HPIP is upregulated in colorectal cancer and regulates colorectal cancer cell proliferation, apoptosis and invasion

• DOI: 10.1038/srep09429
• Publication Date: 2015-03-24T06:04:08Z
• Authors: Yingying Feng; Xiaojie Xu; Yunjing Zhang; Jianhua Ding; Yonggang Wang; Xiaopeng Zhang; Zhe Wu; Lei Kang; Yingchun Liang; LiYing Zhou; Santai Song; Ke Zhao; Qinong Ye
• Keywords: 0301 basic medicine; Epithelial-Mesenchymal Transition; Gene Expression; Cell Cycle Proteins; Apoptosis; Cancer research; Gene; Article; Pathology and Forensic Medicine; Mice; Molecular Characterization of Colorectal Cancer; Cell growth; 03 medical and health sciences; Cell Movement; Cell Line, Tumor; Biochemistry, Genetics and Molecular Biology; Health Sciences; Genetics; Animals; Humans; Molecular Biology; Biology; Internal medicine; Cell Proliferation; Cancer; Cell Cycle; Intracellular Signaling Peptides and Proteins; The p53 Signaling Network in Cancer Research; Life Sciences; Colorectal cancer; Downregulation and upregulation; Up-Regulation; Molecular Mechanisms of DNA Damage Response; 3. Good health; Disease Models, Animal; Oncology; Gene Knockdown Techniques; FOS: Biological sciences; Heterografts; Medicine; Cancer Therapy; Mitogen-Activated Protein Kinases; Colorectal Neoplasms; Proto-Oncogene Proteins c-akt

Abstract Hematopoietic pre-B cell leukemia transcription factor (PBX)-interacting protein (HPIP) was shown to play a role in cancer development and progression. However, the of HPIP colorectal (CRC) is unknown. Here, we report that overexpressed most CRC patients predicts poor clinical outcome CRC. promotes proliferation via activation G1/S G2/M checkpoint transitions, concomitant with marked increase positive cycle regulators, including cyclin D1, A B1. inhibits apoptosis accompanied by decreased levels BAX PIG3, inducers increased level inhibitor BCL2. blocks caspase-3-mediated cleavage PARP, an important marker. migration invasion regulates epithelial-mesenchymal transition (EMT), which plays critical invasion. Activation MAPK/ERK1/2 PI3k/AKT pathways required for modulation proliferation, EMT. Moreover, knockdown suppresses tumor growth nude mice. These data highlight progression suggest may be useful target therapy.