MiRNA and TF co-regulatory network analysis for the pathology and recurrence of myocardial infarction

0303 health sciences Myocardial Infarction Computational Biology Reproducibility of Results Article MicroRNAs 03 medical and health sciences Gene Expression Regulation Recurrence Databases, Genetic Animals Humans Gene Regulatory Networks RNA Interference RNA, Messenger Signal Transduction Transcription Factors
DOI: 10.1038/srep09653 Publication Date: 2015-04-13T16:42:57Z
ABSTRACT
Myocardial infarction (MI) is a leading cause of death in the world and many genes are involved it. Transcription factor (TFs) microRNAs (miRNAs) key regulators gene expression. We hypothesized that miRNAs TFs might play combinatory regulatory roles MI. After collecting MI candidate from various resources, we constructed comprehensive MI-specific miRNA-TF co-regulatory network by integrating predicted experimentally validated TF miRNA targets. found some hub nodes (e.g. miR-16 miR-26) this important regulators, can be severed as bridge to interpret associations previous results, which shown case miR-29 study. also for recurrence several DAB2, BMP6, miR-320 miR-103), abnormal expressions may potential mechanisms markers recurrence. At last proposed cellular model discuss major with signaling pathways This study provides more details on expression regulation progression It linked up interpreted results.
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