MiRNA and TF co-regulatory network analysis for the pathology and recurrence of myocardial infarction

• DOI: 10.1038/srep09653
• Publication Date: 2015-04-13T16:42:57Z
• Authors: Ying Lin; Vusumuzi Leroy Si...; Hong-Mei Zhang; Hui Hu; Hui Liu; An-Yuan Guo
• Keywords: 0303 health sciences; Myocardial Infarction; Computational Biology; Reproducibility of Results; Article; MicroRNAs; 03 medical and health sciences; Gene Expression Regulation; Recurrence; Databases, Genetic; Animals; Humans; Gene Regulatory Networks; RNA Interference; RNA, Messenger; Signal Transduction; Transcription Factors

Myocardial infarction (MI) is a leading cause of death in the world and many genes are involved it. Transcription factor (TFs) microRNAs (miRNAs) key regulators gene expression. We hypothesized that miRNAs TFs might play combinatory regulatory roles MI. After collecting MI candidate from various resources, we constructed comprehensive MI-specific miRNA-TF co-regulatory network by integrating predicted experimentally validated TF miRNA targets. found some hub nodes (e.g. miR-16 miR-26) this important regulators, can be severed as bridge to interpret associations previous results, which shown case miR-29 study. also for recurrence several DAB2, BMP6, miR-320 miR-103), abnormal expressions may potential mechanisms markers recurrence. At last proposed cellular model discuss major with signaling pathways This study provides more details on expression regulation progression It linked up interpreted results.