MiRNA and TF co-regulatory network analysis for the pathology and recurrence of myocardial infarction
0303 health sciences
Myocardial Infarction
Computational Biology
Reproducibility of Results
Article
MicroRNAs
03 medical and health sciences
Gene Expression Regulation
Recurrence
Databases, Genetic
Animals
Humans
Gene Regulatory Networks
RNA Interference
RNA, Messenger
Signal Transduction
Transcription Factors
DOI:
10.1038/srep09653
Publication Date:
2015-04-13T16:42:57Z
AUTHORS (6)
ABSTRACT
Myocardial infarction (MI) is a leading cause of death in the world and many genes are involved it. Transcription factor (TFs) microRNAs (miRNAs) key regulators gene expression. We hypothesized that miRNAs TFs might play combinatory regulatory roles MI. After collecting MI candidate from various resources, we constructed comprehensive MI-specific miRNA-TF co-regulatory network by integrating predicted experimentally validated TF miRNA targets. found some hub nodes (e.g. miR-16 miR-26) this important regulators, can be severed as bridge to interpret associations previous results, which shown case miR-29 study. also for recurrence several DAB2, BMP6, miR-320 miR-103), abnormal expressions may potential mechanisms markers recurrence. At last proposed cellular model discuss major with signaling pathways This study provides more details on expression regulation progression It linked up interpreted results.
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