Scopolamine effects on functional brain connectivity: a pharmacological model of Alzheimer’s disease

• DOI: 10.1038/srep09748
• Publication Date: 2015-07-01T09:14:19Z
• Authors: R. Bajo; S. Pusil; M. E. López; L. Canuet; E. Pereda; D. Osipova; F. Maestú; E. Pekkonen
• Keywords: Scopolamine; Magnetoencephalography

Abstract Scopolamine administration may be considered as a psychopharmacological model of Alzheimer’s disease (AD). Here, we studied group healthy elderly under scopolamine to test whether it elicits similar changes in brain connectivity those observed AD, thereby verifying possible AD impairment. We did by testing subjects two experimental conditions: glycopyrrolate (placebo) and administration. then analyzed magnetoencephalographic (MEG) data corresponding both conditions resting-state with eyes closed. This analysis was performed source space combining nonlinear frequency band-specific measure functional (phase locking value, PLV) network methods. Under scopolamine, between several areas significantly reduced compared placebo, most bands analyzed. Besides, regarding the complex indices (clustering shortest path length), clustering decreased alpha band while length increased also after Overall our findings indicate that PLV graph are suitable tools induced which causes alterations apparently reported AD.