Multiple MoS2 Transistors for Sensing Molecule Interaction Kinetics

• DOI: 10.1038/srep10546
• Publication Date: 2015-05-27T13:36:25Z
• Authors: Hongsuk Nam; Bo-Ram Oh; Pengyu Chen; Mikai Chen; Sungjin Wi; Wenjie Wan; Katsuo Kurabayashi; Xiaogan Liang
• Keywords: Biomolecule; Subthreshold conduction

Abstract Atomically layered transition metal dichalcogenides (TMDCs) exhibit a significant potential to enable next-generation low-cost transistor biosensors that permit single-molecule-level quantification of biomolecules. To realize such biosensing capability, device-oriented research is needed for calibrating the sensor responses affinities/kinetics biomolecule interactions. In this work, we demonstrated MoS 2 -based capable detecting tumor necrosis factor – alpha (TNF-α) with detection limit as low 60 fM. Such was achieved in both linear and subthreshold regimes transistors. regimes, all sets transistors exhibited consistent calibrated respect TNF-α concentration they resulted standard curve, from which equilibrium constant antibody-(TNF-α) pair extracted be K D = 369 ± 48 Based on model, time-dependent binding kinetics also measured association/dissociation rates were (5.03 0.16) × 10 8 M −1 s (1.97 0.08) −4 , respectively. This work advanced critical device physics leveraging excellent electronic/structural properties TMDCs applications well capability analyzing interactions fM-level sensitivities.