RETRACTED ARTICLE: Tumor-specific Th2 responses inhibit growth of CT26 colon-cancer cells in mice via converting intratumor regulatory T cells to Th9 cells

• DOI: 10.1038/srep10665
• Publication Date: 2015-06-02T16:30:28Z
• Authors: Jiang-Qi Liu; Xing-Yong Li; Hai-Qiong Yu; Gui Yang; Zhi-Qiang Liu; Xiao-Rui Geng; Shuai Wang; Li-Hua Mo; Lu Zeng; Miao Zhao; Yun-Ting Fu; Hong-Zhi Sun; Zhi-Gang Liu; Ping-Chang Yang
• Keywords: Male; 0301 basic medicine; 0303 health sciences; Apoptosis; T-Cell Antigen Receptor Specificity; T-Lymphocytes, Helper-Inducer; T-Lymphocytes, Regulatory; Article; 3. Good health; Disease Models, Animal; Mice; 03 medical and health sciences; Lymphocytes, Tumor-Infiltrating; Th2 Cells; T-Lymphocyte Subsets; Cell Line, Tumor; Colonic Neoplasms; Animals

AbstractThe abnormality of immune regulation plays a critical role in the pathogenesis of cancer; the underlying mechanism has not been fully understood yet. This study aims to investigate the role of cancer specific T helper (Th)2 response in the inhibition of colon cancer (Cca) cell growth. The results showed that with Cca cell (CT26 cell) extracts as an antigen, the Cca-extract specific Th2 response was induced in the Cca-bearing mice. The Cca mass size was significantly reduced, or radically disappeared (5 out of 10; or 50%); the survival rate was markedly improved in mice immunized with Cca-extract, but not in those immunized with another tumor cell (U87 cell) extracts or to bovine serum albumin. The immunization with Cca-extract also induced Cca cell apoptosis and converted the intra-Cca Tregs to T helper (Th) 9 cells. In conclusion, Cca-specific Th2 responses inhibit Cca growth in a mouse model via inducing Cca cell apoptosis and converting intra-Cca Tregs to Th9 cells.