14-3-3ζ deficient mice in the BALB/c background display behavioural and anatomical defects associated with neurodevelopmental disorders

• DOI: 10.1038/srep12434
• Publication Date: 2015-07-24T12:34:45Z
• Authors: Xiangjun Xu; Emily J. Jaehne; Zarina Greenberg; Peter McCarthy; Eiman Saleh; Clare L. Parish; Daria Camera; Julian Heng; Matilda Haas; Bernhard T. Baune; Udani Ratnayake; Maarten van den B...; Angel F. Lopez; Hayley S. Ramshaw; Quenten Schwarz
• Keywords: Congenic

Abstract Sequencing and expression analyses implicate 14-3-3ζ as a genetic risk factor for neurodevelopmental disorders such schizophrenia autism. In support of this notion, we recently found that −/− mice in the Sv/129 background display schizophrenia-like defects. As epistatic interactions play significant role disease pathogenesis generated new congenic strain BALB/c to determine impact on phenotype. addition replicating defects aberrant mossy fibre connectivity impaired spatial memory, our analysis identified enlarged lateral ventricles, reduced synaptic density ectopically positioned pyramidal neurons all subfields hippocampus. contrast previous analyses, lacked locomotor hyperactivity was underscored by normal levels dopamine transporter (DAT) signalling. Taken together, results demonstrate dysfunction gives rise many pathological hallmarks associated with human condition. 14-3-3ζ-deficient therefore provide novel model address underlying biology structural affecting hippocampus ventricle cognitive hippocampal-dependent learning memory.