Copy number variation-based genome wide association study reveals additional variants contributing to meat quality in Swine

• DOI: 10.1038/srep12535
• Publication Date: 2015-08-03T10:20:48Z
• Authors: Ligang Wang; Lingyang Xu; Xin Liu; Tian Zhang; Na Li; El Hamidi Hay; Yuebo Zhang; Hua Yan; Kebin Zhao; George E Liu; Longchao Zhang; Lixian Wang
• Keywords: Genome-wide Association Study; Genetic Association

Abstract Pork quality is important both to the meat processing industry and consumers’ purchasing attitude. Copy number variation (CNV) a burgeoning kind of variants that may influence quality. In this study, genome-wide association study (GWAS) was performed between CNVs traits in swine. After false discovery rate (FDR) correction, total 8 on 6 chromosomes were identified be significantly associated with at least one trait. All verified by next generation sequencing six them qPCR. Only haplotype block containing CNV12 adjacent significant SNPs quality, suggesting effects those not likely captured tag SNPs. The DNA dosage EST expression CNV12, which overlap an obesity related gene Netrin-1 ( Ntn1 ), consistent RNA expression, might involved regulation finally We concluded contribute genetic variations beyond several candidate worth further exploration.