Enhanced anti-ischemic stroke of ZL006 by T7-conjugated PEGylated liposomes drug delivery system

• DOI: 10.1038/srep12651
• Publication Date: 2015-07-29T10:02:10Z
• Authors: Zhongyuan Wang; Yue Zhao; Yan Jiang; Wei Lv; Lin Wu; Baoyan Wang; Lingyan Lv; Qunwei Xu; Hongliang Xin
• Keywords: Nanocarriers; Biodistribution

The treatment for ischemic stroke is one of the most challenging problems and therapeutic effect remains unsatisfied due to poor permeation drugs across blood brain barrier (BBB). In this study, HAIYPRH (T7), a peptide that targeted transferrin receptor (TfR) can mediate transport nanocarriers BBB, was conjugated liposomes targeting novel neuroprotectant (ZL006). T7-conjugated PEGylated (T7-P-LPs) loaded with ZL006 (T7-P-LPs/ZL006) were showed satisfactory vesicle size distribution. Furthermore, cellular uptake results T7 modification increased by capillary endothelial cells (BCECs) little cytotoxicity or without observed. in vivo biodistribution near-infrared fluorescence imaging evidenced rendered significantly enhanced BBB. pharmacodynamic study suggested that, T7-P-LPs/ZL006 exhibited reduced infarct volume ameliorated neurological deficit compared unmodified free ZL006. could be displayed remarkable neuroprotective effects. They used as potential drug delivery system treatment.