Obesity changes the human gut mycobiome

• DOI: 10.1038/srep14600
• Publication Date: 2015-10-12T08:51:42Z
• Authors: M. Mar Rodríguez; Daniel Pérez; Felipe Javier Chaves; Eduardo Esteve; Pablo Marin-Garcia; Gemma Xifra; Joan Vendrell; Mariona Jové; Reinald Pamplona; Wifredo Ricart; Manuel Portero-Otin; Matilde R. Chacón; José Manuel Ferná...
• Keywords: Adult; Blood Glucose; Male; Intestines -- Microbiology; Article; Glutamates; Overweight persons; Humans; Obesity; Mycological Typing Techniques; Caproates; Candida; 2. Zero hunger; Cholesterol, HDL; 1. No poverty; Intestins -- Malalties; Fasting; Middle Aged; Persones obeses; 6. Clean water; Gastrointestinal Microbiome; 3. Good health; Intestines; Intestins -- Microbiologia; Aspergillus; Adipose Tissue; Mucor; Case-Control Studies; DNA, Intergenic; Female; Intestines -- Diseases

Abstract The human intestine is home to a diverse range of bacterial and fungal species, forming an ecological community that contributes normal physiology disease susceptibility. Here, the microbiota (mycobiome) in obese non-obese subjects was characterized using Internal Transcribed Spacer (ITS)-based sequencing. results demonstrate patients could be discriminated by their specific composition, which also distinguished metabolically “healthy” from “unhealthy” obesity. Clusters according genus abundance co-segregated with body fatness, fasting triglycerides HDL-cholesterol. A preliminary link metabolites such as hexadecanedioic acid, caproic acid N-acetyl-L-glutamic found. Mucor racemosus M. fuscus were species more represented compared counterparts. Interestingly, decreased relative reversible upon weight loss. Collectively, these findings suggest manipulation gut mycobiome communities might novel target treatment