Obesity changes the human gut mycobiome
Adult
Blood Glucose
Male
Intestines -- Microbiology
Article
Glutamates
Overweight persons
Humans
Obesity
Mycological Typing Techniques
Caproates
Candida
2. Zero hunger
Cholesterol, HDL
1. No poverty
Intestins -- Malalties
Fasting
Middle Aged
Persones obeses
6. Clean water
Gastrointestinal Microbiome
3. Good health
Intestines
Intestins -- Microbiologia
Aspergillus
Adipose Tissue
Mucor
Case-Control Studies
DNA, Intergenic
Female
Intestines -- Diseases
DOI:
10.1038/srep14600
Publication Date:
2015-10-12T08:51:42Z
AUTHORS (13)
ABSTRACT
AbstractThe human intestine is home to a diverse range of bacterial and fungal species, forming an ecological community that contributes to normal physiology and disease susceptibility. Here, the fungal microbiota (mycobiome) in obese and non-obese subjects was characterized using Internal Transcribed Spacer (ITS)-based sequencing. The results demonstrate that obese patients could be discriminated by their specific fungal composition, which also distinguished metabolically “healthy” from “unhealthy” obesity. Clusters according to genus abundance co-segregated with body fatness, fasting triglycerides and HDL-cholesterol. A preliminary link to metabolites such as hexadecanedioic acid, caproic acid and N-acetyl-L-glutamic acid was also found.Mucor racemosusandM. fuscuswere the species more represented in non-obese subjects compared to obese counterparts. Interestingly, the decreased relative abundance of theMucorgenus in obese subjects was reversible upon weight loss. Collectively, these findings suggest that manipulation of gut mycobiome communities might be a novel target in the treatment of obesity.
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