Obesity changes the human gut mycobiome

Adult Blood Glucose Male Intestines -- Microbiology Article Glutamates Overweight persons Humans Obesity Mycological Typing Techniques Caproates Candida 2. Zero hunger Cholesterol, HDL 1. No poverty Intestins -- Malalties Fasting Middle Aged Persones obeses 6. Clean water Gastrointestinal Microbiome 3. Good health Intestines Intestins -- Microbiologia Aspergillus Adipose Tissue Mucor Case-Control Studies DNA, Intergenic Female Intestines -- Diseases
DOI: 10.1038/srep14600 Publication Date: 2015-10-12T08:51:42Z
ABSTRACT
AbstractThe human intestine is home to a diverse range of bacterial and fungal species, forming an ecological community that contributes to normal physiology and disease susceptibility. Here, the fungal microbiota (mycobiome) in obese and non-obese subjects was characterized using Internal Transcribed Spacer (ITS)-based sequencing. The results demonstrate that obese patients could be discriminated by their specific fungal composition, which also distinguished metabolically “healthy” from “unhealthy” obesity. Clusters according to genus abundance co-segregated with body fatness, fasting triglycerides and HDL-cholesterol. A preliminary link to metabolites such as hexadecanedioic acid, caproic acid and N-acetyl-L-glutamic acid was also found.Mucor racemosusandM. fuscuswere the species more represented in non-obese subjects compared to obese counterparts. Interestingly, the decreased relative abundance of theMucorgenus in obese subjects was reversible upon weight loss. Collectively, these findings suggest that manipulation of gut mycobiome communities might be a novel target in the treatment of obesity.
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