Estrogen accelerates the resolution of inflammation in macrophagic cells

• DOI: 10.1038/srep15224
• Publication Date: 2015-10-19T09:46:43Z
• Authors: Alessandro Villa; Nicoletta Rizzi; Elisabetta Vegeto; Paolo Ciana; Adriana Maggi
• Keywords: Homeostasis

Abstract Although 17β-estradiol (E 2 ) anti-inflammatory activity has been well described, very little is known about the effects of this hormone on resolution phase inflammatory process. Here, we identified a previously unreported ERα-mediated effect E machinery. The study showed that activation intracellular estrogen receptor shortens LPS-induced pro-inflammatory and, by influencing intrinsic and extrinsic programs, triggers inflammation in RAW 264.7 cells. Through regulation SOCS3 STAT3 signaling pathways, facilitates progression process toward IL10-dependent “acquired deactivation” phenotype, which responsible for tissue remodeling restoration homeostatic conditions. present may provide an explanation increased susceptibility to chronic diseases women after menopause it suggests novel treatments such disorders.