Novel genes associated with lymph node metastasis in triple negative breast cancer

• DOI: 10.1038/srep15832
• Publication Date: 2015-11-05T09:05:24Z
• Authors: Andrea Mathe; Michelle Wong-Brown; Brianna Morten; John F. Forbes; Stephen G. Braye; Kelly A. Avery-Ki...; Rodney J. Scott
• Keywords: Triple-negative breast cancer

Abstract Triple negative breast cancer (TNBC) is the most aggressive subtype with worst prognosis and no targeted treatments. TNBC patients are more likely to develop metastases relapse than other subtypes. We aimed identify TNBC-specific genes associated lymph node metastasis, one of first signs metastatic spread. A total 33 TNBCs were used; 17 which had matched normal adjacent tissues available 15 metastases. Gene expression microarray analysis was used reveal that differentially expressed between these groups. identified validated 66 significantly altered when comparing tumours samples. Further, we 83 metastasis correlated miRNA-expression. Pathway revealed their involvement in DNA repair, recombination cell death, chromosomal instability known cancer-related pathways. Finally, four specific for TNBC, overall survival. This study has novel involved LN may be as treatment targets or prognostic indicators future.