Cognitive impairment in a young marmoset reveals lateral ventriculomegaly and a mild hippocampal atrophy: a case report

• DOI: 10.1038/srep16046
• Publication Date: 2015-11-03T09:47:57Z
• Authors: A. Sadoun; K. Strelnikov; E. Bonté; C. Fonta; P. Girard
• Keywords: Ventriculomegaly; Abnormality

Abstract The number of studies that use the common marmoset ( Callithrix jacchus ) in various fields neurosciences is increasing dramatically. In general, animals enter study when their health status considered satisfactory on basis classical clinical investigations. behavioral studies, variations score between individuals are frequently observed, some them being as poor performers or outliers. Experimenters rarely consider fact it could be related to brain anomaly. This raises important issue reliability such approaches without using complementary imaging, especially lacking striking external signs. Here we report case a young which presented set cognitive impairments two different tasks compared other age-matched animals. Brain imaging revealed patent right lateral ventricular enlargement with mild hippocampal atrophy. abnormality explain this animal. Such points importance complementing by explorations avoid experimental bias.