Flower-like PEGylated MoS2 nanoflakes for near-infrared photothermal cancer therapy

• DOI: 10.1038/srep17422
• Publication Date: 2015-12-03T10:47:40Z
• Authors: Wei Feng; Liang Chen; Ming Qin; Xiaojun Zhou; Qianqian Zhang; Yingke Miao; Kexin Qiu; Yanzhong Zhang; Chuanglong He
• Keywords: Photothermal effect; Biocompatibility

Abstract Photothermal cancer therapy has attracted considerable interest for treatment in recent years, but the effective photothermal agents remain to be explored before this strategy can applied clinically. In study, we therefore develop flower-like molybdenum disulfide (MoS 2 ) nanoflakes and investigate their potential ablation of cells. MoS are synthesized via a facile hydrothermal method then modified with lipoic acid-terminated polyethylene glycol (LA-PEG), endowing obtained high colloidal stability very low cytotoxicity. Upon irradiation near infrared (NIR) laser at 808 nm, showed powerful ability inducing higher temperature, good conversion efficiency. The vitro effects -PEG different concentrations were also evaluated under various power densities NIR 808-nm results indicated that an killing cells could achieved by concentration irradiation. Furthermore, cell vivo efficiently destroyed effect These thus suggest would as promising future therapy.