The TLR2 is activated by sporozoites and suppresses intrahepatic rodent malaria parasite development

• DOI: 10.1038/srep18239
• Publication Date: 2015-12-15T10:03:06Z
• Authors: Hong Zheng; Zhangping Tan; TaoLi Zhou; Feng Zhu; Yan Ding; Taiping Liu; Yuzhang Wu; Wenyue Xu
• Keywords: Plasmodium yoelii; Proinflammatory cytokine

Abstract TLRs (Toll-like receptors) play an important role in the initiation of innate immune responses against invading microorganisms. Although several have been reported to be involved response blood-stage malaria parasites, development pre-erythrocytic stage is still largely unknown. Here, we found that sporozoite and its lysate could significantly activate TLR2 induce macrophages release proinflammatory cytokines, including IL-6, MCP-1 TNF-α, a TLR2-dependent manner. Further studies showed recognized by either homodimers or TLR2/1 TLR2/6 heterodimers, implicating complexity agonist sporozoite. Interestingly, signaling can suppress Plasmodium yoelii , as both liver parasite load subsequent parasitemia were elevated TLR2- MyD88-deficient mice. Additionally, observed higher level burden −/− mice was closely associated with reduction cytokines liver. Therefore, provide first evidence sporozoites signaling, which turn inhibits intrahepatic parasites. This may us novel clues design preventive anti-malaria therapies.