Overexpression of sonic hedgehog in the triple negative breast cancer: clinicopathological characteristics of high burden breast cancer patients from Bangladesh

• DOI: 10.1038/srep18830
• Publication Date: 2016-01-05T09:48:28Z
• Authors: A. S. Noman; M. Uddin; M. Z. Rahman; M. J. Nayeem; S. S. Alam; Z. Khatun; M. Wahiduzzaman; A. Sultana; M. L. Rahman; M. Y. Ali; D. Barua; I. Ahmed; M. S. Islam; A. Aboussekhra; H. Yeger; W. A. Farhat; S. S. Islam
• Keywords: Triple negative; Triple-negative breast cancer

Dysregulation of Hedgehog (Hh) signaling pathway has been documented in mammary gland development and breast cancer (BC) progression. Despite the remarkable progress therapeutic interventions, BC related mortality Bangladesh increased last decade. Triple negative (TNBC) still presents a critical challenge. Thus effective targeted therapy is urgently needed. In this study, we report clinicopathological characteristics prognosis patients from Bangladesh. Routine immunohistochemical analysis high throughput RNA-Seq data TCGA library were used to analyze expression pattern association low level Shh collection with long-term follow-up. High levels observed subset tumors poor prognostic pathological features. Higher correlated significantly poorer overall survival compared whose expressed Shh. These support contention that could be novel biomarker for involved mediating aggressive phenotype BC. We propose exhibiting higher expression, representing patients, would amenable therapy.