Gene targets of mouse miR-709: regulation of distinct pools

• DOI: 10.1038/srep18958
• Publication Date: 2016-01-08T11:19:55Z
• Authors: Sneha Surendran; Victoria N. Jideonwo; Chris Merchun; Miwon Ahn; John Murray; Jennifer Ryan; Kenneth W. Dunn; Janaiah Kota; Núria Morral
• Keywords: Reprogramming

Abstract MicroRNA (miRNA) are short non-coding RNA molecules that regulate multiple cellular processes, including development, cell differentiation, proliferation and death. Nevertheless, little is known on whether miRNA control the same gene networks in different tissues. miR-709 an abundant expressed ubiquitously. Through transcriptome analysis, we have identified targets of hepatocytes. represses genes implicated cytoskeleton organization, extracellular matrix attachment fatty acid metabolism. Remarkably, none previously non-hepatic tissues silenced by hepatocytes, even though several these abundantly liver. In addition, upregulated hepatocellular carcinoma, suggesting it participates genetic reprogramming takes place during division, when remodeling requires substantial changes expression. summary, present study shows does not repress pool separate types. These results underscore need for validating every tissue a expressed.