Endothelial cell dysfunction and cardiac hypertrophy in the STOX1 model of preeclampsia

• DOI: 10.1038/srep19196
• Publication Date: 2016-01-13T11:54:36Z
• Authors: Aurélien Ducat; Ludivine Doridot; Rosamaria Calicchio; Celine Méhats; Jean-Luc Vilotte; Johann Castille; Sandrine Barbaux; Betty Couderc; Sébastien Jacques; Franck Letourneur; Christophe Buffat; Fabien Le Grand; Paul Laissue; Francisco Miralles; Daniel Vaiman
• Keywords: Endothelial Dysfunction

Abstract Preeclampsia is a disease of pregnancy involving systemic endothelial dysfunction. However, cardiovascular consequences preeclampsia are difficult to analyze in humans. The objective the present study evaluate dysfunction induced by examining endothelium mice suffering severe STOX1 overexpression. Using Next Generation Sequencing on cells carrying either transgenic or control embryos, we discovered significant alterations gene networks involved inflammation, cell cycle and cardiac hypertrophy. In addition, heart preeclamptic revealed hypertrophy associated with histological anomalies. Bioinformatics comparison modified genes HUVECs exposed plasma from women identified striking similarities. pregnant comparable those endured system women. could help better understand context guide search for efficient therapies able protect maternal during its aftermath.