Architecture and Function of Mechanosensitive Membrane Protein Lattices

• DOI: 10.1038/srep19214
• Publication Date: 2016-01-14T14:15:11Z
• Authors: Osman Kahraman; Peter D. Koch; William S. Klug; Christoph A. Hase...
• Keywords: Lattice (music)

Abstract Experiments have revealed that membrane proteins can form two-dimensional clusters with regular translational and orientational protein arrangements, which may allow cells to modulate function. However, the physical mechanisms yielding supramolecular organization collective function of remain largely unknown. Here we show bilayer-mediated elastic interactions between yield distinctive lattice architectures provide a link architecture Using mechanosensitive channel large conductance (MscL) as model system, obtain relations shape MscL lattices. We predict tetrameric pentameric symmetries observed in previous structural studies distinct that, turn, these activation barriers. Our results suggest general linking symmetry,