Branched-chain and aromatic amino acid profiles and diabetes risk in Chinese populations

• DOI: 10.1038/srep20594
• Publication Date: 2016-02-05T10:31:51Z
• Authors: Tianlu Chen; Yan Ni; Xiaojing Ma; Yuqian Bao; Jiajian Liu; Fengjie Huang; Cheng Hu; Guoxiang Xie; Aihua Zhao; Weiping Jia; Wei Jia
• Keywords: Isoleucine

Abstract Recent studies revealed strong evidence that branched-chain and aromatic amino acids (BCAAs AAAs) are closely associated with the risk of developing type 2 diabetes in several Western countries. The aim this study was to evaluate potential role BCAAs AAAs predicting development Chinese populations. serum levels valine, leucine, isoleucine, tyrosine, phenylalanine were measured a longitudinal cross sectional total 429 participants at different stages development, using an ultra-performance liquid chromatography triple quadruple mass spectrometry platform. alterations five AAs populations well accordance previous reports. Early elevation their combined score future diabetes, suggesting important these metabolites as early markers diabetes. On other hand, not good existing clinical differentiating diabetic patients from healthy counterparts. Our findings verified close correlation insulin resistance highlighted predictive value for