Co-transfection of decorin and interleukin-10 modulates pro-fibrotic extracellular matrix gene expression in human tenocyte culture

• DOI: 10.1038/srep20922
• Publication Date: 2016-02-10T10:24:23Z
• Authors: Sunny A. Abbah; Dilip Thomas; Shane Browne; Timothy O’Brien; Abhay Pandit; Dimitrios I. Zeug...
• Keywords: Matrix (chemical analysis)

Abstract Extracellular matrix synthesis and remodelling are driven by increased activity of transforming growth factor beta 1 (TGF-β1). In tendon tissue repair, TGF-β1 leads to progressive fibrosis. Decorin (DCN) interleukin 10 (IL-10) antagonise pathological collagen exerting a neutralising effect via downregulation TGF-β1. Herein, we report that the delivery DCN IL-10 transgenes from hydrogel system supresses constitutive expression range pro-fibrotic extracellular genes.