Risk Factors for Steatorrhea in Chronic Pancreatitis: A Cohort of 2,153 Patients

• DOI: 10.1038/srep21381
• Publication Date: 2016-02-15T10:29:34Z
• Authors: Bai-Rong Li; Jun Pan; Ting-Ting Du; Zhuan Liao; Bo Ye; Wen-Bin Zou; Hui Chen; Jun-Tao Ji; Zhao-Hong Zheng; Dan Wang; Jin-Huan Lin; Shou-Bin Ning; Liang-Hao Hu; Zhao-Shen Li
• Keywords: Steatorrhea; Alcohol abuse

Abstract This study aimed to investigate the occurrence of and determine risk factors for steatorrhea in chronic pancreatitis (CP). It was based on analysis both retrospectively prospectively acquired database CP patients admitted our center from January 2000 December 2013. Demographic data, course disease, medical history follow-up evaluations were documented detail. Cumulative rate calculated by using Kaplan–Meier method. For factor analysis, multivariate Cox proportional hazards regression model performed. A total 2,153 included with a mean duration 9.3 years. Approximately 14% (291/2,153) presented at diagnosis CP. rates 1, 5, 10 20 years after 4.27% (95% CI: 3.42%–5.34%), 12.53% 10.74%–14.59%), 20.44% 17.37%–23.98%) 30.82% 20.20%–45.21%), respectively. Male gender (HR = 1.771, p 0.004), diabetes 1.923, < 0.001), alcohol abuse 1.503, 0.025) pancreaticoduodenectomy 2.901, 0.001) independent while adolescents 0.433, 0.009) protective factor. In conclusion, male gender, adult, diabetes, lead increased patients.