A nanoparticulate pre-chemosensitizer for efficacious chemotherapy of multidrug resistant breast cancer

• DOI: 10.1038/srep21459
• Publication Date: 2016-02-15T10:32:25Z
• Authors: Shengrong Guo; Li Lv; Yuanyuan Shen; Zhongliang Hu; Qianjun He; Xiaoyuan Chen
• Keywords: Chemosensitizer; Nanocarriers

Abstract Small-molecule chemosensitizers can reverse cancer multidrug resistance (MDR), thus significantly improving the in vitro effect of chemotherapy drugs for MDR cells, however, their vivo effects are not always very good, because they difficult to effectively accumulate tumor and enter same with after systemic administration due individual biopharmaceutical properties. To overcome these limitations, here we study a novel nanoparticular pre-chemosensitizer which be also used as nanocarrier drugs. We take an ‘all one’ approach develop self-assembled nanoparticle formula amphiphilic poly(curcumin-dithiodipropionic acid)-b-poly(ethylene glycol)-biotin. The is capable tumor-targeted delivery, responsive degradation at intracellular level glutathione subsequent co-release chemosensitizer curcumin encapsulated chemotherapeutic drug doxorubicin maximize synergistic chemosensitization chemotherapy. demonstrate that antitumor efficacy much superior resistant MCF-7/ADR xenografted nude mice.