Age-related neurogenesis decline in the subventricular zone is associated with specific cell cycle regulation changes in activated neural stem cells

• DOI: 10.1038/srep21505
• Publication Date: 2016-02-19T10:42:43Z
• Authors: Mathieu Daynac; Lise Morizur; Alexandra Chichep...; Marc-André Mouthon; François D. Boussin
• Keywords: Progenitor

Abstract Although neural stem cells (NSCs) sustain continuous neurogenesis throughout the adult lifespan of mammals, they progressively exhibit proliferation defects that contribute to a sharp reduction in subventricular during aging. However, little is known regarding early age-related events neurogenic niches. Using fluorescence-activated cell sorting technique allows for prospective purification main populations from zone (SVZ), we demonstrated an decline with dramatic loss progenitor 4 month-old young mice. Whereas activated and quiescent NSC pools remained stable up 12 months, proliferative status NSCs was already altered by 6 overall extension cycle resulting specific lengthening G 1 . Whole genome analysis 2- 6-month-old mice further revealed distinct transcriptomic molecular signatures, as well modulation TGFβ signalling pathway. Our microarray study constitutes cogent identification new players pathways regulating its modifications.