Discovery of a Novel Seminal Fluid Microbiome and Influence of Estrogen Receptor Alpha Genetic Status

• DOI: 10.1038/srep23027
• Publication Date: 2016-03-14T07:13:31Z
• Authors: Angela B. Javurek; William G. Spollen; Amber M. Mann Ali; Sarah A. Johnson; Dennis B. Lubahn; Nathan J. Bivens; Karen H. Bromert; Mark R. Ellersieck; Scott A. Givan; Cheryl S. Rosenfeld
• Keywords: Lachnospiraceae; Estrogen receptor alpha

Abstract Bacteria harbored in the male reproductive system may influence function and health of result developmental origins adult disease (DOHaD) effects his offspring. Such could be due to seminal fluid, which is slightly basic enriched with carbohydrates; thereby, creating an ideal habitat for microbes or a potential fluid microbiome (SFM). Using wild-type (WT) estrogen receptor-alpha (ESR1) knockout (KO) mice, we describe unique SFM whose inhabitants differ from gut microbes. The bacterial composition influenced according whether mice have functional Esr1 genes. Propionibacterium acnes , causative agent chronic prostatitis possibly culminating prostate cancer, reduced ESR1 KO compared WT (P ≤ 0.0007). In certain genetic backgrounds, show greater incidence cancer than KO, increased abundance P. . Additionally, select residents males, such as Lachnospiraceae Christensenellaceae, might contribute previously identified phenotypes, especially obesity, these mutant mice. Understanding how genetics environmental factors provide next frontier disorders paternal-based DOHaD diseases.