Effectiveness of Multiple Blood-Cleansing Interventions in Sepsis, Characterized in Rats

• DOI: 10.1038/srep24719
• Publication Date: 2016-04-21T09:04:55Z
• Authors: Ivan Stojkovic; Mohamed Ghalwash; Xi Hang Cao; Zoran Obradovic
• Keywords: Combination therapy

Sepsis is a serious, life-threatening condition that presents growing problem in medicine, but there still no satisfying solution for treating it. Several blood cleansing approaches recently gained attention as promising interventions target the main site of development-the blood. The focus this study an evaluation theoretical effectiveness hemoadsorption therapy and pathogen reduction therapy. This evaluated using mathematical model Murine sepsis, results over 2,200 configurations single multiple intervention therapies simulated on 5,000 virtual subjects suggest advantage However, combination two found to take their complementary effects outperform either alone. conducted computational experiments provide unprecedented evidence synergistically enhances positive beyond simple superposition benefits approaches. Such characteristic could have profound influence way sepsis treatment conducted.