Microbial metabolite butyrate facilitates M2 macrophage polarization and function

• DOI: 10.1038/srep24838
• Publication Date: 2016-04-20T09:51:53Z
• Authors: Jian Ji; Dingming Shu; Mingzhu Zheng; Jie Wang; Chenglong Luo; Yan Wang; Fuyou Guo; Xian Zou; Xiaohui Lv; Ying Li; Tianfei Liu; Hao Qu
• Keywords: Macrophage polarization; Sodium butyrate; M2 Macrophage

Abstract Metabolites from intestinal microbes modulate the mucosal immune system by regulating polarization and expansion of T cells. Whether microbial metabolites influence macrophage polarization, however, is poorly understood. Here, we show that large bowel fermentation product, butyrate, facilitates M2 in vitro vivo . The supernatant butyrate-treated increased migration enhanced wound closure rate MLE-12 Butyrate attenuated inflammation mice with dextran sulfate sodium (DSS)-induced colitis, a significant increase colonic expression macrophage-associated protein, Arg1. treated had activation H3K9/STAT6 signaling pathway, suggesting mechanism for butyrate facilitated polarization. Collectively, our study indicated commensal microbe-derived novel activator STAT6-mediated transcription through H3K9 acetylation driving delineated new insights into interplay underlying inflammatory disease.