Patients with first-episode, drug-naive schizophrenia and subjects at ultra-high risk of psychosis shared increased cerebellar-default mode network connectivity at rest

• DOI: 10.1038/srep26124
• Publication Date: 2016-05-18T09:03:53Z
• Authors: Houliang Wang; Wenbin Guo; Feng Liu; Guodong Wang; Hailong Lyu; Renrong Wu; Jindong Chen; Shuai Wang; Lehua Li; Jingping Zhao
• Keywords: Drug-naïve; Posterior cingulate

Increased cerebellar-default mode network (DMN) connectivity has been observed in first-episode, drug-naive patients with schizophrenia. However, it remains unclear whether increased cerebellar-DMN starts earlier than disease onset. Thirty-four ultra-high risk (UHR) subjects, 31 schizophrenia and 37 healthy controls were enrolled for a resting-state scan. The imaging data analyzed using the seed-based functional (FC) method. Compared controls, UHR subjects shared between right Crus I bilateral posterior cingulate cortex/precuneus Lobule IX left superior medial prefrontal cortex. There are positive correlations I-bilateral precuneus clinical variables (Structured Interview Prodromal Syndromes/Positive Negative Symptom Scale negative symptoms/total scores) subjects. by not only highlights importance of DMN pathophysiology psychosis but also may be trait alteration psychosis.