Hyperhomocysteinaemia in rats is associated with erectile dysfunction by impairing endothelial nitric oxide synthase activity

• DOI: 10.1038/srep26647
• Publication Date: 2016-05-25T09:24:22Z
• Authors: Weijun Jiang; Lei Xiong; Bin Yang; Weiwei Li; Jing Zhang; Qing Zhou; Qiuyue Wu; Tianfu Li; Cui Zhang; Mingchao Zhang; Xinyi Xia
• Keywords: Endothelial Dysfunction

Abstract To investigate the effect of hyperhomocysteinaemia (HHCy) on penile erectile function in a rat model, methionine-rich diet was used which function, reproductive system, and nitric oxide synthase were characterized. The intracavernous pressure, apomorphine experiments, measurement oxidative stress, hematoxylin eosin staining, immunohistochemistry analysis, reverse transcription-polymerase chain reactions endothelial activity utilized. Our results showed that erections middle-dose, high-dose, interference (INF) groups significantly lower than control ( P < 0.05). INF group, being fed with vitamins B folic acid, demonstrated markedly improved compared middle-dose group HHCy-induced eNOS phospho-eNOS protein expression reduced antioxidant impaired. data present provide evidence HHCy is vascular risk factor for dysfunction by impairing cavernosa activity. Intake can alleviate this abnormality.