miR-21-5p renal expression is associated with fibrosis and renal survival in patients with IgA nephropathy

• DOI: 10.1038/srep27209
• Publication Date: 2016-06-06T09:42:02Z
• Authors: Marie-Flore Hennino; David Buob; Cynthia Van der H...; Viviane Gnemmi; Zacharie Jomaa; Nicolas Pottier; Grégoire Savary; Elodie Drumez; Christian Noël; Christelle Cauffiez; François Glowacki
• Keywords: Adult; Male; 0301 basic medicine; Glomerulonephritis, IGA; Middle Aged; Kidney; [SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology; [SDV.MHEP.UN] Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology; Fibrosis; Article; Up-Regulation; MicroRNAs; Young Adult; 03 medical and health sciences; Risk Factors; Humans; Female

AbstractIgA nephropathy (IgAN) is the most prevalent primary glomerulonephritis, whose prognosis is highly variable. Interstitial fibrosis is a strong independent prognosis factor. Among microRNA involved in renal fibrogenesis, only few have been investigated in IgAN. In the context of IgAN, we aimed to analyze the role of miR-21-5p, miR-214-3p and miR-199a-5p, three established “fibromiRs” involved in renal fibrosis. Fifty-six IgAN biopsy specimens were retrospectively scored according to Oxford classification. Renal expression of miR-21-5p, miR-214-3p and miR-199a-5p were significantly associated with T score (miR-21-5p T0 RQ median = 1.23, T1 RQ = 3.01, T2 RQ = 3.90; miR-214-5p T0 RQ = 1.39, T1 RQ = 2.20, T2 RQ = 2.48; miR-199a-5p T0 RQ = 0.76, T1 RQ = 1.41, T2 RQ = 1.87). miR-21-5p expression was associated with S score (S0 RQ median = 1.31, S1 RQ = 2.65), but not miR-214-3p nor miR-199a-5p. In our cohort, poor renal survival was associated with high blood pressure, proteinuria and elevated creatininemia, as well as T and S scores. Moreover, renal expression of miR-21-5p, miR-214-3p were associated with renal survival. In conclusion, miR-21-5p, miR-214-3p and miR-199a-5p are three “fibromiRs” involved in renal fibrosis in the course of IgAN and miR-21-5p and miR-214-3p are associated with renal survival.