Focused ultrasound-enhanced intranasal brain delivery of brain-derived neurotrophic factor

• DOI: 10.1038/srep28599
• Publication Date: 2016-06-27T09:27:51Z
• Authors: Hong Chen; Georgiana Zong Xi...; Hoheteberhan Geta...; Camilo Acosta; Carlos Sierra Sán...; Elisa E. Konofagou
• Keywords: Sonication

Abstract The objective of this study was to unveil the potential mechanism focused ultrasound (FUS)-enhanced intranasal (IN) brain drug delivery and assess its feasibility in therapeutic molecules. Delivery outcomes fluorescently-labeled dextrans mouse brains by IN administration either before or after FUS sonication were compared evaluate whether enhances active pumping passive diffusion. Fluorescence imaging slices found that followed achieved significantly higher than only, while pre-treatment not different from only. Brain-derived neurotrophic factor (BDNF), a promising for treatment many central nervous system diseases, delivered demonstrate technique with established where drugs are injected intravenously. Immunohistochemistry staining BDNF revealed FUS-enhanced similar locally enhanced as technique. This suggested FUS-induced demonstrated is noninvasive localized molecules brain.