Lipidomic Signatures and Associated Transcriptomic Profiles of Clear Cell Renal Cell Carcinoma

• DOI: 10.1038/srep28932
• Publication Date: 2016-06-30T09:22:03Z
• Authors: Kosuke Saito; Eri Arai; Keiko Maekawa; Masaki Ishikawa; Hiroyuki Fujimoto; Ryo Taguchi; Kenji Matsumoto; Yae Kanai; Yoshiro Saito
• Keywords: Phosphatidylethanolamine; Renal cortex; Sphingolipid; Lipidome

Abstract Renal cell carcinoma (RCC) is the most common histological type of adult kidney cancer. In this study, we obtained lipidomic profiles clear RCC (ccRCC), a major subtype, by performing analysis specimens cancerous tissue and surrounding normal renal cortex from same patients ( N = 49). We also compared with lipogenic transcriptome for an additional set patient samples 95). Overall, detected 326 lipids, including phospholipids, sphingolipids, neutral eicosanoids. The levels more than 70% lipids were significantly different P < 0.01, corrected false discovery rate). was distinguished higher ether-type cholesterol esters, triacylglycerols, as well lower phospholipids (except phosphatidylcholines) polyunsaturated fatty acids. Characteristic changes in mRNAs metabolites suggested that phosphatidylethanolamine (PE) synthesis pathway suppressed ccRCC associated proliferation. present study represents ccRCC, which provides novel information about metabolic pathophysiology.