Curcumin ameliorates neuropathic pain by down-regulating spinal IL-1β via suppressing astroglial NALP1 inflammasome and JAK2-STAT3 signalling

• DOI: 10.1038/srep28956
• Publication Date: 2016-07-06T09:06:21Z
• Authors: Shenbin Liu; Qian Li; Meng-Ting Zhang; Qi-Liang Mao-Ying; Lang-Yue Hu; Gen-Cheng Wu; Wen-Li Mi; Yan-Qing Wang
• Keywords: Janus kinase 2

Abstract Curcumin has been shown to possess strong anti-inflammatory activity in many diseases. It demonstrated that the janus kinase 2 (JAK2)-signal transducer and activator of transcription 3 (STAT3) cascade NAcht leucine-rich-repeat protein 1 (NALP1) inflammasome are important for synthesis Pro-Interleukin (IL)-1β processing inactive its mature form, which plays an active role pathogenesis neuropathic pain. The present study showed repeated intraperitoneal injection curcumin ameliorated SNI-induced mechanical cold allodynia a dose-dependent manner inhibited elevation spinal IL-1β levels. Additionally, treatment significantly aggregation NALP1 activation JAK2-STAT3 astrocytes. Furthermore, genetic down-regulation by siRNA pharmacological inhibition AG490 markedly maturation Pro-IL-1β synthesis, respectively reduced pain hypersensitivity. Our results suggest attenuated down-regulated production inhibiting