Research on the printability of hydrogels in 3D bioprinting

• DOI: 10.1038/srep29977
• Publication Date: 2016-07-20T09:34:34Z
• Authors: Yong He; FeiFei Yang; HaiMing Zhao; Qing Gao; Bing Xia; JianZhong Fu
• Keywords: Three dimensional printing; 3D bioprinting; Biocompatible material

Abstract As the biocompatible materials, hydrogels have been widely used in three- dimensional (3D) bioprinting/organ printing to load cell for tissue engineering. It is important precisely control deposition during mimic organ structures. However, printability of about parameters seldom addressed. In this paper, we systemically investigated from lines (one dimensional, 1D structures) lattices/films (two 2D and 3D structures with a special attention accurate printing. After series experiments, discovered relationships between factors such as air pressure, feedrate, or even distance quality expected Dumbbell shape was observed lattice due hydrogel diffuses at intersection. Collapses fusion adjacent layer would result error accumulation Z direction which an fact that could cause failure. Finally, successfully demonstrated scaffold through harmonize all parameters. The viability after compared casting results showed our bioprinting method almost had no extra damage cells.